Good question. It would only matter if any RTP voice traffic is being proxied via Voxalot (US or EU) instead of calls going directly between your IP and the calling destination's IP in the UK. If this were the case, then registering with the eu voxalot would be better. However if it were not the case, then registering via the proxy closest to you is in general better. In any event make sure DNS SRV settings are enabled in your device so that you can take advantage of server fallback if the main server you are using goes offline.
Normally Voxalot acting as a man-in-the-middle doesn't happen unless your SIP device settings are bad and a firewall or NAT is blocking you. You can confirm you are not being outbound-proxied via Voxalot by disabling "Enable symmetric NAT handling" in your Voxalot profile and then trying to place calls. At that point, the calls are definitely point-to-point without Voxalot, or they just plain won't work.
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